3,3′-Diindolylmethane——Good helper of hormone regulation

3,3′-Diindolylmethane widely exists in natural plants of Cruciferae. It has important biological and pharmacological activities. It is also an effective radiation protector and mitigation agent. It stimulates ATM driven DDR like response and NF- κ B to function as a survival signal. 3,3 ‘- diindole methane can regulate signal pathways, such as Akt and NF- κ B and FoxO3 to inhibit tumor cell invasion, angiogenesis, proliferation and induce apoptosis. It can also inhibit estrogen induced gene expression and cause endoplasmic reticulum stress response. 3,3 ‘- diindole methane can change estrogen metabolism and antagonize estrogen and androgen receptor activities.

3,3 ‘- diindolemethane is an effective radiation protector and mitigation agent by stimulating ATM driven DDR like response and NF- κ B to function as a survival signal. Dim can regulate signal pathways, such as Akt and NF- κ B and FoxO3 to inhibit tumor cell invasion, angiogenesis, proliferation and induce apoptosis. It can also inhibit estrogen induced gene expression and cause endoplasmic reticulum stress response.

3,3 ‘- diindole methane can improve intestinal permeability. Some studies have found that 3,3′ – diindole methane can repair the intestinal permeability of differentiated Caco-2 cells by increasing the expression of tight junction protein. Compared with the original IL-1 β The transmembrane resistance of Caco-2 cells treated with dim increased significantly from 551.0 ± 49.0 Ω· cm2 to 919.0 ± 66.4 Ω· cm2. In addition, dim can also improve the impaired intestinal permeability and prolong the life of C. elegans treated with Pseudomonas aeruginosa, from an average of 9.7 ± 1.1 days to 10.8 ± 1.3 days. Therefore, dim is also good for intestinal permeability.

3,3 ‘- diindole methane helps the human body fight aging and promote the healthy balance of testosterone in the body. Testosterone supports energy, promotes a happy mood, and helps maintain healthy sexuality. In addition, zegligs pointed out that 3,3 ‘- diindole methane has anti-aging effect and may help to promote lean body weight. Combined with exercise, you can increase muscle mass.