At present the most important veterinary clinical anti-infective drug-Amoxicillin Sodium

Beta-lactam antibiotics are currently the most important veterinary clinical anti-infective drugs, semi-synthetic penicillin developed in the 1960s. Amoxicillin (Amoxicillin), also known as amoxicillin, is a semi-synthetic acid-resistant broad-spectrum penicillin antibiotic. The drug has a broad antibacterial spectrum, strong bactericidal power, and rapid action. It is effective against major Gram-positive bacteria and some negative bacteria such as streptococcus, pasteurella, staphylococci that do not produce penicillinase, E. coli, salmonella, and Proteus mirabilis They are all sensitive and can be widely used to treat various bacterial infections of the urethra, respiratory tract and skin of various animals. Amoxicillin has the following characteristics than penicillin antibiotics: the antibacterial spectrum is wider, it has a higher sterilization effect on anaerobic bacteria, and the allergic reaction is lower; therefore, amoxicillin is more effective than penicillin Even better, it is a class of antibiotics that is currently highly valued. At present, it has been approved for use in cattle, dogs, and cats abroad, and there are reports of treatment studies in pigs and sheep.

Amoxicillin sodium is the sodium salt of amoxicillin, which is a penicillin antibiotic. The pharmacological effect is the same as that of amoxicillin. The mechanism of action is to inhibit bacterial cell wall synthesis. The target molecule is the penicillin binding protein PBPs on the cell wall, and some PBPs belong to Lysozyme, once activated, will cause bacterial cell lysis. By inhibiting these PBPs, bacteria are deformed and cell division is delayed. This process occurs during the reproduction period of bacterial cells, so this kind of drug is a bactericidal agent during the reproduction period, and Toxicity to animals without cell wall. For aerobic Gram-positive cocci such as Streptococcus pneumoniae and Hemolytic streptococci, penicillinase-free Staphylococcus, Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella, Haemophilus influenzae, The aerobic gram-negative bacteria such as Neisseria gonorrhoeae and beta-lactamase-producing strains and Helicobacter pylori have good antibacterial activity.