Dihydroxyl Theophylline has a strong effect of relaxing bronchial smooth muscle, exciting the heart and diuretic.

Dihydroxyl Theophylline is also known as Chuan Ding, the chemical name is 1,3-dimethyl-7- (2,3 dihydroxypropyl) -3,7-dihydro-1H-purine-2,6-dione, It is a commonly used antiasthmatic drug in clinic. It is a xanthine derivative condensed with theophylline and monochlorodipropanol. The antiasthmatic effect is similar to aminophylline. Its bronchodilatory effect is about 1/10 of aminophylline. Only 1/20 to 1/10 of aminophylline. This product has a small pain response to intramuscular injection, and oral administration has little irritation to the gastrointestinal tract. The oral bioavailability is 70%, and the half-life is about 2 hours. It is not metabolized in the body, and most of it is excreted with urine in its original form. Clinically used for the relief of wheezing symptoms such as bronchial asthma, asthmatic bronchitis, obstructive emphysema. It can also be used for cardiogenic asthma, especially for asthma patients with tachycardia and intolerance to theophylline. Theophylline is an alkaloid present in plants such as tea and coffee. It is a derivative of methylxanthine and has a strong effect of relaxing bronchial smooth muscle, exciting the heart and diuretic.

Theophylline is widely used clinically, mainly for the treatment of bronchial asthma, cardiogenic asthma and cardiogenic edema. When theophylline is used as a bronchodilator, it is necessary to strictly control its effective concentration in the plasma (5-20 mg / L) to avoid side effects due to excessive concentration. Aminophylline is a double salt of theophylline and ethylenediamine. Its pharmacological effect mainly comes from theophylline, and ethylenediamine enhances its water solubility. This product has a direct relaxation effect on respiratory smooth muscle. In addition, theophylline is a purine receptor blocker, which can resist the contraction of adenine and other respiratory tracts. Theophylline can enhance diaphragmatic contractility, especially when diaphragm contraction is weak, so it is beneficial to improve respiratory function. This product can weakly relax coronary arteries, peripheral blood vessels and biliary smooth muscle, and slightly increase myocardial contractility and slight diuresis.