Isoniazid — chemical synthesis of anti-tuberculosis drugs

Isoniazid is a chemically synthesized anti-tuberculosis drug. It is also called Remi seal, it is artificially synthesized and has the characteristics of high curative effect, low toxicity, convenient oral administration and low price. It is still the first choice for anti-tuberculosis. Isoniazid has a strong effect on Mycobacterium tuberculosis with high specificity and can penetrate cells. The minimum bacteriostatic concentration is 0.02 ～ 0.05μg / ml. It has sterilization effect at higher concentration. It does not directly inhibit the development of bacteria but only prevents them from multiplying when they divide to a certain extent. The antibacterial mechanism of isoniazid is unclear. Some people think that isoniazid can affect the lipids on which Mycobacterium tuberculosis depends to reduce lipid and reduce its acid resistance. Some people think that isoniazid can inhibit the biosynthesis of mycolic acid of Mycobacterium tuberculosis, which is unique to mycobacteria. Isoniazid inhibits the acid chain of mycobacteria by inhibiting mycolase synthetase It cannot be extended. Isoniazid has a strong antibacterial effect and is not affected by serum. It is one of the most effective drugs among anti-tuberculosis drugs and is suitable for the treatment of various tuberculosis. The oral dose is 4 to 6 mg / kg per day. The resistance of Mycobacterium tuberculosis to isoniazid develops faster, although it is generally believed that the resistance of Mycobacterium tuberculosis that produces drug resistance decreases. In order to delay the resistance of isoniazid and enhance the efficacy, it is often combined with streptomycin and p-aminosalicylic acid.

This product has a strong inhibitory and killing effect on tuberculosis bacillus. It is also effective against tuberculosis bacillus inside and outside the cell. It is the drug of choice for anti-tuberculosis. It has a small dosage, is easy to take orally, and can penetrate the blood-brain barrier as tuberculous meningitis Of choice. It is used clinically for the development stage, dissolution and dissemination period, absorption improvement period and active pulmonary tuberculosis of various types of tuberculosis. For old sclerosing tuberculosis, the effect is not significant.