Methyltestosterone——The key to male development

Methyltestosterone is a kind of androgen drug, clinically mainly used to promote the development of male sexual organs and side characteristics and maintain their normal functions. It is also used for functional uterine bleeding and migratory breast cancer in women. It can also be used for Synthetic methyl testosterone propionate and other advanced androgen drugs have a huge market. Methyltestosterone plays an important physiological role in men from the early embryonic stage and different growth stages. In the sexual differentiation of male fetuses, methyltestosterone plays a key role. Methyl testosterone also promotes growth of bones. The growth of bones is mediated by growth hormone. Methyl testosterone increases the secretion of growth hormone and also increases the growth rate of height.

Methyltestosterone can promote the development and maturation of male sexual organs and side characteristics; fight estrogen, inhibit endometrial growth and ovarian and pituitary function; promote protein synthesis and bone formation, stimulate bone marrow hematopoietic function, and increase red blood cells and hemoglobin . It is clinically used for male hypogonadism, anorchidism, cryptic disease, menorrhagia, uterine fibroids, endometriosis, senile osteoporosis, and aplastic anemia in children.

The traditional production method of methyltestosterone is to extract diosgenin from the dioscorea plant. After protection, oxidative cracking and elimination, the key intermediate obtained-gestation dienolone acetate (abbreviated as diene) is used as the raw material and oximated , Beckman rearrangement, acid hydrolysis, Grignard reaction, alkaline hydrolysis, Austenite oxidation and other six-step reactions. Among them, the extraction, oxidative pyrolysis, Beckman rearrangement, acid and alkali hydrolysis reactions of diosgenin produce a lot of waste water, which is difficult to handle and easy to pollute the environment; the Austenite oxidation process used in production requires steam distillation and consumes Water consumes a lot of energy. More importantly, as wild yam plant resources are increasingly depleted, and artificially planted yam plants, the growing costs of artificial and chemical fertilizers have caused the production cost of saponin and diene to double, resulting in methyl testosterone. The substantial increase in production costs and market prices has already had a significant impact on the global methyltestosterone drug market.