Vitamin D2—-Mainly used to prevent rickets and osteomalacia
Ergocalciferol is the chemical name of vitamin D2. Ergocalciferol is a ring-opening steroid formed by the chemical bond breakage of steroids under photochemical action, especially can be produced by the action of ultraviolet rays and ergosterol.
The world consumption of vitamin D2 is 1800 tons/year, of which 70%-80% is used for feed additives. China has a large population and most children lack calcium, so the incidence of rickets is high, while the prevalence of osteoporosis in the elderly is more than twice that in developed countries. Therefore, the normal demand for vitamin D2 by children and the elderly alone reaches tens of tons per year. With the improvement of people’s living standards, the Chinese people’s demand for health care products is increasing. They are eager to improve the body’s immunity through the scientific diet, to achieve the purpose of health, intelligence, and longevity. Many developed countries, such as Japan and the United States, have introduced fortified foods containing vitamin D2 since the 1970s. According to statistics, China’s annual demand for edible and medicinal vitamin D2 reaches 100 tons, plus the feed industry’s demand, China’s annual demand for vitamin D2 can reach 200 tons, so vitamin D2 has good development prospects.
This product is a vitamin medicine. Vitamin D2 promotes the absorption of calcium by the brush border of the small intestine mucosa and the reabsorption of phosphorus by the renal tubules, increases blood calcium and blood phosphorus concentration, cooperates with parathyroid hormone (PTH), calcitonin (CT), and promotes the release of calcium phosphate from old bones. Maintain and regulate the normal concentration of plasma calcium and phosphorus. Vitamin D2 promotes calcium deposition at the site of new bone formation, deposits citrate in bone, promotes bone calcification and osteoblast function and bone-like tissue maturation. After ingestion of vitamin D2, it is catalyzed by the 25-hydroxylase system to produce calcidiol (25-OHD3) in the cell microsomes, and catalyzed by the 1-hydroxylase system of the renal proximal tubule cells to produce biologically active bone Triol [1-25-(OH)2D3]. In animal experiments, after excising the parathyroid gland of the mouse, 1-hydroxylase activity was lost and calcitriol could not be synthesized. During hypercalcemia, CT secretion increases and 1-hydroxylase activity is inhibited, which reduces the conversion of calcidiol to calcitriol. It is confirmed that calcitriol metabolism is regulated by PTH and CT, and phosphate and calcium can also be Regulates 1-hydroxylase activity.
Indications:
1. For the prevention and treatment of vitamin D deficiency. Such as: absolute vegetarians, patients with parenteral nutrition, pancreatic insufficiency with malabsorption syndrome, hepatobiliary diseases (hepatic dysfunction, cirrhosis, obstructive jaundice), small intestinal diseases (fatty diarrhea, localized enteritis, long-term diarrhea), stomach Excision, etc.
2. Used for chronic hypocalcemia, hypophosphatemia, rickets and osteomalacia with chronic renal insufficiency, familial hypophosphatemia and hypoparathyroidism (postoperative, idiopathic or pseudo) Treatment of hypoparathyroidism).
3. It is used to treat acute, chronic, and latent operative hand-foot twitch syndrome and idiopathic hand-foot twitch syndrome.
