Pyridoxal 5 Phosphate Monohydrate
Name: Pyridoxal 5 Phosphate Monohydrate CAS: 41468-25-1 Feature: Pyridoxal 5 Phosphate Monohydrate acts as a coenzyme in all transamination reactions, and in certain decarboxylation, deamination, and racemization reactions of amino acids. The aldehyde group of Pyridoxal 5 Phosphate Monohydrate forms a Schiff-base linkage (internal aldimine) with the ε-amino group of a specific lysine group of the aminotransferase enzyme. The α-amino group of the amino acid substrate displaces the ε-amino group of the active-site lysine residue in a process known as transaldimination. The resulting external aldimine can lose a proton, carbon dioxide, or an amino acid sidechain to become a quinonoid intermediate, which in turn can act as a nucleophile in several reaction pathways. Pyridoxal 5 Phosphate Monohydrate is also involved in various beta-elimination reactions such as the reactions carried out by serine dehydratase and GDP-4-keto-6-deoxymannose-3-dehydratase (ColD).It is also active in the condensation reaction in heme synthesis. Pyridoxal 5 Phosphate Monohydrate plays a role in the conversion of levodopa into dopamine, facilitates the conversion of the excitatory neurotransmitter glutamate to the inhibitory neurotransmitter GABA, and allows SAM to be decarboxylated to form propylamine, which is a precursor to polyamines. Pyridoxal 5 Phosphate Monohydrate has the following applications/functions:
  1. Metabolism and biosynthesis of serotonin. Pyridoxal 5 Phosphate Monohydrate is a cofactor of aromatic L-amino acids decarboxylase. This allows for conversion of 5-hydroxytryptophan (5-HTP) into serotonine (5-HT). This reaction takes place in serotonergic neurons.
  2. Metabolism and biosynthesis of histamine. Pyridoxal 5 Phosphate Monohydrate is a cofactor of L-histidine decarboxylase. This allows for conversion of histidine into histamine. This reaction takes place in Golgi apparatus in mast cells and in basophils. Next, histamine is stored in granularity in mast cells as a complex with acid residues of heparin proteoglycan while in basophils as a complex with chondroitine sulfate.
  3. Metabolism and biosynthesis of GABA (γ-aminobutyric acid). Pyridoxal 5 Phosphate Monohydratee is a cofactor of glutamic acid decarboxylase (GAD). This allows for conversion of glutamate into GABA. Reaction takes place in cytoplasm of termination of GABA-ergic neurons, therefore vitamin B6 deficiency may cause epileptic seizures in children. Pyridoxal phosphate also participates in the oxidative deamination of GABA, where it is a cofactor of GABA aminotransferase.
  4. Metabolism of ornithine. Pyridoxal 5 Phosphate Monohydrate is a cofactor of ornithine carboxylase.
  5. Transamination. Pyridoxal 5 Phosphate Monohydrate takes part in decomposition and synthesis of amino acids.
Composition:  Appearance: Light yellow powder Assay: ≥99% Packing: 25kg/drum or as discussed Shelf Life: 2 years Storage: Store in cool and dry area Certification:ISO GMP KOSHER HALAL
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