Calcium Alpha-Ketoglutarate——Regulate immunity and maintain body balance
Calcium ketoglutarate is one of the two keto derivatives of glutaric acid. It is a white fine crystalline powder. Its salts are important biological compounds. Calcium ketoglutarate is an important biological compound. It is a ketoacid product of glutamic acid deamination and an intermediate product of the tricarboxylic acid cycle. Calcium ketoglutarate participates in the tricarboxylic acid cycle in vivo, generates amino acids, and can be used as a dietary supplement. Help to improve the performance of athletes.
Calcium ketoglutarate can reduce protein catabolism and increase protein synthesis in human body to enhance bone formation in skeletal muscle. As we all know, protein in the human body is an essential element for muscle synthesis, but a large part of protein in the human body is not decomposed and absorbed, but discharged through the urine. Therefore, calcium ketoglutarate intake can effectively curb the loss of protein in the body, improve the absorption and utilization of protein, and make it more easily absorbed amino acids.
Calcium ketoglutarate can also delay human aging and reduce the body loss of patients with long-term illness. Calcium ketoglutarate is an important metabolic intermediate in the microbial tricarboxylic acid cycle. It is the key node connecting the intracellular carbon nitrogen metabolism. Its position in the cycle is after isocitrate and before succinyl coenzyme A. In this region, the complement reaction can be produced by transamination from glutamate α- Ketoglutarate can supplement the intermediate metabolite. It can prolong the life span by inhibiting ATP synthase and tor.
Calcium ketoglutarate can stabilize the homeostasis of immune system. It is also called immunotrophic factor and plays an important role in general immune metabolism. It is well known that calcium ketoglutarate is an important source of glutamine and glutamate, which is defined as glutamine homologues and derivatives. Glutamine is an important fuel for lymphocytes and macrophages. Therefore, calcium ketoglutarate, a glutamine homologue, has the characteristics of immune enhancement, which can maintain the intestinal barrier, increase the activity and phagocytosis of immune cells and neutrophils, and reduce bacterial translocation.
