Fenbendazole is a broad-spectrum, high-efficiency and low-toxic benzimidazole insect repellent

Fenbendazole is white or off-white powder, odorless and tasteless. This product is dissolved in dimethyl sulfoxide, slightly soluble in methanol, insoluble in water, and soluble in glacial acetic acid. Fenbendazole is a benzimidazole anthelmintic, which not only has a high anthelmintic activity against gastrointestinal nematodes, adults and larvae, but also has a good effect on net tail nematodes, laminaria and tapeworms, and has a strong killing effect. Insect eggs.

The detailed pharmacological effects of fenbendazole are:

(1) Sheep-tooth sheep nematode, Oster nematode, Trichostrongylus sp., Cooper nematode, Nematode nematode, Yangtella elegans, Chabot nematode, Esophageal nematode, Trichoderma elegans and Net-tail nematode adults and larvae All have excellent insect repellent effect. In addition, it can inhibit the spawning of most gastrointestinal nematodes. The application of high-dose doses also has a good effect on the expansion of the tapeworm of Moniz and the tapeworm of Moniz. However, continuous application of large doses of flukes can be effective. For example, 20 mg/kg for 5 days and 15 mg/kg for 6 days to drive off the double-chamber flukes and liver flukes.

(2) The deworming spectrum of cattle to cattle is roughly similar to that of sheep. For example, it is highly effective against blood worm nematode, Oster nematode, trichostrongylus spp, nematode nematode, nematode nematode, cooper nematode, esophageal nematode, fetal reticulate nematode adult and larvae. However, for Fasciola hepatica and schistosomiasis, it is necessary to apply a dose of 7.5 to 10 mg/kg for 6 days to be effective. Fenbendazole also inhibits spawning of nematodes. Once administered, no eggs will be excreted in feces after 22 to 36 hours.

(3) Horse to round parasites, adult and larvae of horse-tailed nematodes, Platypus elegans, common round nematodes, round nematodes toothless, round nematodes horse, small round nematodes are highly efficient. However, it is not effective against the nematode genus Caenorhabditis elegans, Taenia spp., Strongyloides flexneri, and common round nematode larvae transferred in the mesentery.

(4) Although some people think that one-time administration of fenbendazole is effective against the red swine worm, roundworm, esophageal nematode adult and larvae, the United States currently recommends the continuous administration method to enhance the anthelmintic effect. For example, C. suis, once applied 15mg/kg, the effect is only 65%, and 3mg/kg for 6 days, the anthelmintic effect exceeds 99%. Due to the mixed feeding of 3mg per kilogram body weight, it can be used for 3 consecutive days. For roundworms, esophageal nematodes, red worms, and round worms (effective dose of 25mg/kg in one application), even the removal rate of C. dentata (porcine kidney worms) is almost 100%, plus some Insect species larvae are also quite effective, so they are now widely used abroad.

(5) 50mg/kg daily dose of dogs and cats can be used continuously for 3 days, which is highly effective for hookworms, roundworms and caterpillars of dogs and cats. Daily use of 50 mg/kg daily dose for 5 days against cat lung nematodes (Aelurostrongylusabstrusus); continuous use for 3 days against cat stomach worms (P. elegans; 0llulanus) are the best deworming programs.

(6) Poultry has a good effect on the gastrointestinal and respiratory tract nematodes of poultry. According to the daily dose of 8mg/kg for 6 days, it is highly effective against roundworm, capillaria and tapeworm. The effective dose for turkey roundworms is 350mg/kg, but if fed at a concentration of 45mg/kg for 6 days, all turkey roundworms, anisakis and capillary worms will be eliminated. The best deworming plan for pheasants, partridges, grouses, geese and ducks is 60mg/kg feed concentration for 6 days. Domestic pigeons naturally infected with closed capillary worms and roundworms are mixed with 100mg/kg for 3 to 4 days. The effective rate is almost 100%.

(7) Wild animals Because fenbendazole is safe and reliable for the insect repellent of various wild animals in the zoo, the US FDA has approved special preparations. The following is a brief introduction to cat lion bowworms, lion bowworms, hookworms, banded tapeworms, lion bowworms, banded tapeworms, banded tapeworms (Baylisascaristranstuga), and a few mountain goats in lions, tigers, and leopards. The protozoan nematode of horn sheep can be taken orally at a dose of 10 mg per kg of body weight for 3 days. For wild ruminants, Hippo spp., nematode, trichostrongylus, trichostrongylus, trichomonas, swine roundworm of wild boar, toothed esophageal nematode, crested nematode, 2.5mg and 3mg/kg daily For 3 days. According to other information, 25 mg/kg of raptors that are seriously infected with roundworms, sawdust nematodes, capillary nematodes and flukes can almost eliminate the above-mentioned insects.

(8) Fenbendazole, an insect-killing egg, has an effect on killing the eggs of ruminants Trichodidae, Angiostrongylus suis, Ascaris lumbricoides, hookworms and whipworms of humans and dogs.

Pharmacodynamics Fenbendazole is a novel benzimidazole insect repellent with broad spectrum, high efficiency and low toxicity. It not only has high anthelmintic activity against adult gastrointestinal nematodes and larvae of animals, but also has better effects on net-tail nematodes, spear-shaped flukes, flukes and tapeworms. Fenbendazole is used abroad not only for various animals, but also for special preparations for wild animals.