Flubendazole has an excellent anthelmintic effect on most nematodes, tapeworms and most nematodes in the gastrointestinal tract of pigs

Flubendazole is a white powder, odorless, insoluble in water, and slightly soluble in dilute hydrochloric acid. It is a new benzimidazole insect repellent. It has an excellent anthelmintic effect on most nematodes and tapeworms in the gastrointestinal tract of pigs and most nematodes in the gastrointestinal tract of chickens. It is effective for reusing the weight of immature worms of cysticercosis and echinococcus granulosus. The anthelmintic mechanism is currently believed to interfere with the energy metabolism of the worm.

This product is a new anti-worm drug synthesized in my country in 1983. This product has a satisfactory effect on echinococcosis and cerebral cysticercosis, which currently lack special treatment. It has a good effect on a variety of helminths, including roundworm, whipworm, hookworm, pinworm, stercoralis, Clonorchis sinensis, Clonorchis sinensis, and Xenopsis, and is also effective for hookworm skin migration. In addition, it has a therapeutic effect on scabies. The human body is well tolerated by this product. It has high anti-insect efficacy and a broad spectrum of anti-insects. It can be used to treat a single infection or a mixed infection of several parasites. Oral administration is hardly absorbed by the intestinal mucosa, and 80% is excreted in feces within 3 days.

Flubendazole is the para-fluorine homologue of mebendazole. It is not only effective against gastrointestinal nematodes, but also has certain effects on some tapeworms. Abroad is mainly used for gastrointestinal helminthiasis of pigs and poultry. Pigs are treated with a therapeutic amount (5 mg/kg) for 5 days, which can almost completely eliminate swine roundworm, red swine nematode, toothed esophageal nematode, wild boar angiostrongylus, and trichoderma suis Coccidia must be used continuously for 10 days to control piglet disease.

Flubendazole is currently widely used as a safe and effective anthelmintic for the control of gastrointestinal parasites in humans, rodents and ruminants. Flubendazole is one of the family members of benzimidazole. Not only does it have the typical functions of benzimidazole drugs, but also the added fluorine atom structure gives Flubendazole other functions. For example, recent studies have reported that in leukemia and lymphoma, Flubendazole can inhibit the proliferation of tumor cells by inhibiting tubulin polymerization and delay the formation of tumors in xenograft models. At the same time, Flubendazole also inhibits the resistance of traditional chemotherapy drugs in the treatment of colon cancer. The proliferation and drug resistance of tumor cells are closely related to tumor stem cells. The research of Rosie et al. proved the significant effect of Flubendazole targeting tumor stem cells, suggesting that Flubendazole can be used in the clinical treatment of breast cancer.