Lomefloxacin Hydrochloride — common anti-inflammatory drugs with strong antibacterial effect

Lomefloxacin Hydrochloride is a common anti-inflammatory drug that everyone is familiar with. It belongs to the quinolone synthetic antibiotics. It was first developed jointly by Japan Hokuriku Pharmaceutical Company and Gunma Pharmaceutical Company in 1985. It was first developed by China Pharmaceutical University in the country. The product has the characteristics of wide antibacterial spectrum, long action time, strong antibacterial effect and good clinical efficacy. The inhibitory effect on drug-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli is 1 to 2 of ofloxacin Times, 2 to 4 times that of norfloxacin. In vitro studies have shown that the antibacterial efficacy of lomefloxacin hydrochloride against gram-positive bacteria is stronger than enoxacin, similar to norfloxacin; the antibacterial efficacy against gram-negative bacteria is weaker than that of norfloxacin and ofloxacin Star, similar to enoxacin, but the anti-infection effect in vivo is stronger than the above drugs. After oral administration, the absorption is good. The blood concentration reaches the peak at 1 hour after administration. The tissue fluid is well distributed. The drug concentration in skin, muscle, liver, kidney, prostate, tonsils, saliva, tears, and sputum is higher than the blood concentration. Except for brain tissue, the drug concentration in other tissues is similar to that in blood. The plasma half-life is 7-8 hours, the serum protein binding rate is 20% -30%, and it is almost not metabolized; about 48% -80% of blood drugs are excreted in the urine as prototypes, and are taken with drugs containing aluminum and magnesium , Can reduce the absorption of this product.

【Clinical Application】 Lomefloxacin Hydrochloride has been widely used in the treatment of acute bronchitis, bronchiectasis infection, acute bronchitis, pneumonia and other respiratory diseases caused by sensitive strains, as well as acute pyelonephritis, complicated urinary tract infection, chronic Urinary infections, acute attacks, acute prostatitis, simple gonorrhea and other urinary system infections and abdominal, biliary, intestinal and other infections. It is also used for typhoid fever, bacterial infectious diseases of skin and soft tissues, such as folliculitis, pustulosis, boils, trauma infection and secondary infection of eczema, secondary infection of athlete’s foot, paranasal sinusitis, otitis media, blepharitis, etc.