Mebendazole as an insect repellent is effective against gastrointestinal nematodes in animals

Mebendazole is a broad-spectrum anthelmintic drug, which has the effect of completely killing hookworm eggs and whipworm eggs and partially killing roundworm eggs. It has a strong affinity for the β-tubulin of the worm body. It can be combined with it at a concentration. It can inhibit the aggregation of its microtubules by affecting the metabolism of carbohydrates and the production of related energy, causing the disappearance of the epidermis or intestinal cells of the worm. Ingestion of glucose and other nutrients in the intestinal tract eventually leads to death of the worm. It is suitable for the treatment of human and animal infections caused by whipworm, pinworm, hookworm, tapeworm, stercoralis, roundworm and other single or multiple worms, but it is not effective for hydatid disease. Mebendazole is also an oxidative phosphorylation uncoupling agent, which can inhibit fumarate reductase in mitochondria and reduce glucose transport, thus affecting the production of ATP.

The suspension of mebendazole can inhibit the uptake of glucose by intestinal parasites, leading to the depletion of glycogen stored in the worm body and reducing the formation of ATP in the worm body, but it does not affect the glucose level in the host blood. Observation of ultrastructure, the suspension of mebendazole can cause the microtubules in the cytoplasm of the worm’s envelope cells and intestinal cells to degenerate, so that the secretory particles in the Golgi body can accumulate, causing transport blockage, cytoplasmic dissolution, and absorption of the cells to completely degenerate, which can cause worms. Death.

It can be used to treat monoparasitic parasitic diseases such as fish finger ringworm disease, pseudo finger ringworm disease and third generation worm disease. Dilute this product with 2000 times of water and dilute it evenly. Sprinkle herring, grass carp, silver carp, bighead, mandarin fish and mandarin fish with 67 ～ 100g of original medicine per acre per meter of water. The European eel and American eel use 167 ～ 334g of the original medicine per acre per meter of water, which can be doubled if the condition is serious.