Novel broad-spectrum antiparasitic medicine—Closantel Sodium

Closantel Sodium, also known as cylosalamide sodium salt, Closantel Sodium salt, is the same salicylanilide compound as iodosalamide. Insecticides, yellowish powder in appearance, odorless or slightly odorous, easily soluble in ethanol or acetone, soluble in methanol, insoluble in water or chloroform. The pharmacological effect is to prevent the synthesis of adenosine triphosphate (ATP) in the worm body by inhibiting the mitochondrial phosphorylation process of the worm body, which leads to the rapid decrease of the energy metabolism of the worm body and finally death. Chlorfenapyr sodium can completely kill swine mites, blood lice, roundworms, round worms, nematodes, whipworms, botrytis elegans, nematodes, radiant esophageal nematodes, flukes, and flukes , Capillaria worms, larvae, nasal larvae, ticks, scabies mites, itch mites, nematodes, liver flukes, bots, canine lipid mites and other internal and external parasites of poultry. It has good curative effect on larvae of a variety of flukes, nematodes and arthropods; its anti-trematode repellent activity is mainly directed against Schistosoma hepatica, anti-nematode and anti-arthropod larval repellent activity is mainly directed against various feeding Worms of blood or plasma. The clinical efficacy test shows that when administered at a dose of 10 mg / kg body weight, it has a complete repellent effect on Schistosoma japonicum, Schistosoma japonicum, Pulmonary filariasis and most of the digestive tract nematodes in and outside the body. The best dosage.

Matters needing attention are as follows:

1. Sodium chlorocyanamide injection has certain irritation to local tissues; this product has a long residual period in animals and is not easily degraded and inactivated.

2. The toxicity of this product is low, but when bovine intramuscular injection of 30 mg per kg of body weight can cause visual impairment, blindness, and even death.

3. Drug withdrawal period: 28 days for tablets and suspensions; 28 days for injections, cattle and sheep, and 28 days for milk abandonment.