Procaine HCL —–Widely used local anesthetics

Procaine HCL acts on peripheral nerves to produce conduction block. It relies on the concentration gradient to penetrate the nerve cell membrane in a diffuse manner, and blocks sodium ion channels on the inside, which increases the excitability threshold of nerve cells and loses excitability and conductivity. The transmission is blocked and has a good local anesthetic effect.

Procaine HCL can inhibit monoamine oxidase B, regulate nervous system disorders, inhibit the release of acetylcholine in the presynaptic membrane, produce a certain neuromuscular blocking effect, and directly inhibit smooth muscle, which can relieve smooth muscle spasm. The indication of this drug is to relieve the symptoms of neurasthenia, neurasthenia syndrome and autonomic dysfunction.

Procaine HCL is a commonly used lipid local anesthetic. Its local anesthesia has a short duration of time and can only last for 45 to 60 minutes. Procaine HCL has poor diffusion and penetration, because it has the effect of expanding blood vessels and can be quickly absorbed from the injection site, so the surface anesthesia effect is poor. Small doses inhibit the central nervous system, causing drowsiness and slow pain response. The usage and dosage of procaine: 0.25%-1% is suitable for local infiltration anesthesia, 3%-5% solution can be used for subarachnoid block, the general dosage is 150 mg.

Procaine HCL is mainly used to relieve the pain of intramuscular injection of penicillin, and is also used in dentistry. It mainly acts as a sodium channel blocker. Because of its sympathetic, anti-inflammatory, promote perfusion and improve mood. Relatively old local anesthetics. Mainly used for local infiltration, some are used for spinal anesthesia, and some are used for continuous epidural anesthesia. After a period of time, clinical anesthesiologists researched and developed the use of it as an intravenous drip for intravenous general anesthesia, which can not only achieve sedation, but also have a certain analgesic effect. It is currently a widely used anesthetic.