Tetracycline Hydrochloride is a broad-spectrum bacteriostatic agent with bactericidal effect at high concentration

Tetracycline hydrochloride is a broad-spectrum antibiotic. It has a bactericidal effect at high concentrations. In addition to the common Gram-positive bacteria, Gram-negative bacteria, and anaerobic bacteria, most Rickettsia, Mycoplasma, Chlamydia, and atypical Mycobacterium, spirochete, actinomycete, anthracis, listeria monocytogenes, clostridium, and nocardia are sensitive to this product. The effect of this product on Gram-positive bacteria is better than Gram-negative bacteria, but Enterococcus and Penicillin-resistant Neisseria gonorrhoeae are resistant to it. This product has good antibacterial effect against Gram-negative bacteria such as Vibrio, Brucella, Campylobacter, Yersinia, etc. It has no antibacterial activity against Pseudomonas aeruginosa. The antibacterial mechanism is that the drug can specifically bind to the A position of the 30S subunit of the bacterial ribosome, preventing the connection of the aminoacyl-tRNA at this position, thereby inhibiting the growth of peptide chains and affecting the synthesis of bacterial proteins to produce bacteriostatic effects. And because it can change the permeability of the bacterial cytoplasmic membrane, it is easy to accumulate in the bacterial body, and it has a rapid bacteriostatic effect. Tetracycline hydrochloride is the hydrochloride of tetracycline base. It is further synthesized and refined during the production process. It has high purity, low toxic and side effects, and a long storage period. The percentage of oral absorption is much higher than that of tetracycline base. After entering the human body, the blood drug concentration, urine concentration, and bioavailability are higher than that of tetracycline base, and it is safe, reliable, and the curative effect is accurate. It is still widely used in some countries in Europe and America. Tetracycline hydrochloride is preferred for the treatment of non-bacterial infections such as chlamydia infections, rickettsial disease, mycoplasma pneumonia, and relapsing fever. It is also used for brucellosis, cholera, rabbit fever, rat bite fever, anthrax, tetanus, and plague , The treatment of respiratory system, bile duct, urinary tract infection and skin and soft tissue infection caused by actinomycosis, gas gangrene and sensitive bacteria.