Traditional anticoccidial drug with good anticoccidial effect-amlinoline hydrochloride

Amproline hydrochloride is a white or off-white powder; odorless or almost odorless. This product is soluble in water, slightly soluble in ethanol, very slightly soluble in ether, and insoluble in chloroform. The chemical structure of amphetamine is similar to that of thiamine. It is a traditional anticoccidial drug with good anticoccidial effect. It is still widely used in countries around the world. Alanine can competitively inhibit the uptake of thiamine by coccidia. In cells, thiamine is synthesized into thiamine pyrophosphate, which participates in the oxidative dehydroxylation reaction of α-keto acids during sugar metabolism. It is α-ketone Coenzymes in acid dehydrogenase systems, due to the lack of hydroxyethyl groups of thiamine in aminoproline, cannot be pyrophosphorylated, making many reactions impossible, hindering the sugar metabolism process in the cells of the insect body, and inhibiting the coccidia development. The peak effect of amphetamine on coccidia is to prevent medicine. In addition, it also has a killing effect on the oocysts of the coccidia sexual cycle and spore formation.

Aminopropion has the strongest effect on chicken tender and piled Eimeria, but it has a lesser effect on poison, Brinell, giant, and gentle Eimeria. Usually the therapeutic concentration does not completely inhibit oocyst production. Therefore, at home and abroad, it is often used in combination with ethoxyamide benzyl ester and sulfaquinoxaline to enhance the efficacy. The inhibitory effect of amphetamine on coccidian immunity is not obvious. 120mg / L drinking water concentration can effectively prevent and treat turkey coccidiosis. Because the structure of amphetamine is similar to that of thiamine, it can produce competitive antagonism. If the concentration of amphetamine is too high, it can cause thiamine deficiency in chickens and cause polyneuritis. Although feeding thiamine can restore chicken flock However, it significantly affects the anticoccidial activity of aminoproline. It is reported that when the content of thiamine in a kilogram of feed exceeds 10 mg, the anticoccidial effect of chlorpromline begins to weaken.

It should be noted that: (1) Although this product is stable in nature, it can be mixed with a variety of vitamins, minerals and antibacterial drugs, but it still slowly decomposes in the feed of chickens. When stored at room temperature for 60 days, the average failure is 8%. Therefore, This product should still be ready for use. (2) This product is mostly used in combination with ethoxyamide benzyl methyl ester and sulfaquinoxaline to enhance the efficacy. (3) Laying hens are prohibited. (4) Withdrawal period, broiler chickens for 7 days.